POSTDOCTOTAL POSITION “RECEPTOR SIGNALLING AND AUTOPHAGY IN CANCER” IN KERMORGANT LAB, BARTS CANCER INSTITUTE, LONDON
A three-year post-doc position, funded by the Medical Research Council, is available in the lab of Stéphanie Kermorgant, Barts Cancer Institute, London.
The overall aim of this exciting project is to understand the signalling of the receptor tyrosine kinase c-Met on non-canonical Autophagy Related Endomembranes, “ARE” (Nat. Commun. 2016, 7:11942) in breast and pancreatic cancer. The project will involve: (i) the characterization of ARE; (ii) the determination of the molecular partners of c-Met trafficking and signalling on ARE; (iii) the physiological and pathological relevance of c-Met signalling on ARE.
The post-doc will employ a range of methods including real-time confocal/spinning disk microscopy, CLEM, APEX proximity proteomics and CRISPR/Cas9 gene editing. He/she will also use a range of functional assays including cell invasion in zebrafish embryos and analyse breast/pancreas patient tissues.
Essential requirements for the post include a PhD in a biological subject relevant to this project and strong experience in cell signalling, membrane trafficking and/or autophagy. Experience in proximity proteomic assays would be an advantage.
For informal enquiries about this post email firstname.lastname@example.org. See also the lab web page https://www.bci.qmul.ac.uk/en/staff/item/stephanie-kermorgant.