New paper from Wilkinson lab - CCPG1, a non-canonical autophagy receptor required for ER-phagy

New paper from Wilkinson lab – CCPG1, a non-canonical autophagy receptor required for ER-phagy

The Wilkinson lab (IGMM, Edinburgh) have recently published their work on CCPG1, an ER-resident protein that is required for ER-phagy and prevents ER luminal proteostasis defects in the exocrine pancrease, in vivo.

 

In this study they also show that CCPG1 is a non-canonical autophagy cargo receptor due to the presence of two novel FIP200-interaction region (FIR) motifs (in addition to a canonical LIR morif) that are shown to be required for CCPG1 function.

 

 

Finally, it is shown that the CCPG1 gene is is inducible by the unfolded protein response, providing the first direct evidence of a relationship between ER stress and ER-phagy.

 

Click here to go to paper