New paper from Kermorgant group – Integrin-mediated inside-in signalling via autophagic-related endomembranes
In this paper, Barrow-McGee et al. report a non-adhesive function of β-integrin in receptor tyrosine kinase signalling via a process termed ‘inside-in signalling’. they demonstrate that this mechanism occurs through autophagy-related endomembranes which are independent of Atg13, suggesting it belongs to a non-canonical autophagy pathway.
Interestingly, this study also showed that this signalling supports anchorage-independent cell growth and survival, as well as tumorigenesis and invasion, in vivo.
To read more: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun. 2016;7:11942.