PhD Studentship: The flipside to Parkin – regulation of mitochondrial deubiquitylase activity
£14,057 stipend 3 years PhD Studentship, due to funding, only Home/Eu Students are eligible to apply.
Faculty of Health and Life Sciences, Institute of Translational Medicine, Celluar and Molecular Physiology
Location: University Campus
Closing date for receipt of applications: Thu, 21 Jan 2016 17:00:00 GMT
The PhD project concerns the role of deubiquitylases or DUBs in the process of Parkin-mediated mitophagy. Parkin is an ubiquitin E3-ligase that mediates the clearance of defective mitochondria by ubiquitylating mitochondrial outer membrane proteins. These act as scaffolds for the recruitment of the autophagy machinery. Parkin loss of function mutations have been associated with Parkinson’s disease, presumably due to an increased ROS-burden in dopaminergic neurons of the substantia nigra leading to cell death. Deubiquitylases that oppose Parkin activity are potential therapeutic targets to rescue inefficient mitophagy in a Parkinson’s disease setting. The PhD student will join a dynamic team of cell and molecular biologists working at the interface of neurobiology and cancer research.
You should have, or expect to hold a first or upper second class honours degree in a relevant discipline. Laboratory experience is desirable but not essential.
Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urbé S.
EMBO Rep. 2015 May;16(5):618-27. doi: 10.15252/embr.201439820. Epub 2015 Mar 4.
Heride C, Urbé S, Clague MJ.
Curr Biol. 2014 Mar 17;24(6):R215-20. doi: 10.1016/j.cub.2014.02.002. Review.
Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M.
Nature. 2014 Jun 19;510(7505):370-5. doi: 10.1038/nature13418. Epub 2014 Jun 4.
Including Highlight: Cell biology: balancing act. Ordureau A, Harper JW.
Nature. 2014 Jun 19;510(7505):347-8. doi: 10.1038/nature13500. Epub 2014 Jun 4.
Pickrell AM, Youle RJ.
Neuron. 2015 Jan 21;85(2):257-73. doi: 10.1016/j.neuron.2014.12.007. Review.
Clague MJ, Barsukov I, Coulson JM, Liu H, Rigden DJ, Urbé S.
Physiol Rev. 2013 Jul;93(3):1289-315. doi: 10.1152/physrev.00002.2013. Review.
To apply please send a cover letter summarising your motivation and interest in the project, as well as a CV including details of at least two referees to firstname.lastname@example.org. For application enquires please contact Sylvie Urbé (email@example.com)